Laser additive manufacturing has led to a paradigm shift in the design of next-generation customized porous implants aiming to integrate better with the surrounding bone. However, conflicting design criteria have limited the development of fully functional porous implants; increasing porosity improves body fluid/cell-laden prepolymer permeability at the expense of compromising mechanical stability. Here, functionally gradient porosity implants and scaffolds designed based on interconnected triply periodic minimal surfaces (TPMS) are demonstrated. High local porosity is defined at the implant/tissue interface aiming to improve the biological response. Gradually decreasing porosity from the surface to the center of the porous constructs provides mechanical strength in selective laser melted Ti-6Al-4V implants. The effect of unit cell size is studied to discover the printability limit where the specific surface area is maximized. Furthermore, mechanical studies on the unit cell topology effects suggest that the bending-dominated architectures can provide significantly enhanced strength and deformability, compared to stretching-dominated architectures. A finite element (FE) model developed also showed great predictability (within ?13%) of the mechanical responses of implants to physical activities. Finally, in vitro biocompatibility studies were conducted for two-dimensional (2D) and three-dimensional (3D) cases. The results of the 2D in conjunction with surface roughness show favored physical cell attachment on the implant surface. Also, the results of the 3D biocompatibility study for the scaffolds incorporated with a cell-laden gelatin methacryloyl (GelMA) hydrogel show excellent viability. The design procedure proposed here provides new insights into the development of porous hip implants with simultaneous high mechanical and biological responses.The beneficial role of lithium bis(trimethylsilyl) phosphate (LiTMSP), which may act as a novel bifunctional additive for high-voltage LiNi1.5Mn0.5O4 (LNMO)/graphite cells, has been investigated. LiTMSP is synthesized by heating tris(trimethylsilyl) phosphate with lithium tert-butoxide. The cycle performance of LNMO/graphite cells at 45 °C significantly improved upon incorporation of LiTMSP (0.5 wt %). Nuclear magnetic resonance analysis suggests that the trimethylsilyl (TMS) group in LiTMSP can react with hydrogen fluoride (HF), which is generated through the hydrolysis of lithium hexafluorophosphate (LiPF6) by residual water in an electrolyte solution or water generated via oxidative electrolyte decomposition reactions to form TMS fluoride. Inhibition of HF leads to a decrease in the concentration of transition-metal ion-dissolution (Ni and Mn) from the LNMO electrode, as determined by inductively coupled plasma mass spectrometry. In addition, the generation of the superior passivating surface film derived by LiTMSP on the graphite electrode, suppressing further electrolyte reductive decomposition as well as deterioration/reformation caused by migrated transition metal ions, is supported by a combination of chronoamperometry, X-ray photoelectron spectroscopy, and field-emission scanning electron microscopy. Furthermore, a LiTMSP-derived surface film has better lithium ion conductivity with a decrease in resistance of the graphite electrode, as confirmed by electrochemical impedance spectroscopy, leading to improvement in the rate performance of LNMO/graphite cells. The HF-scavenging and film-forming effects of LiTMPS are responsible for the less polarization of LNMO/graphite cells enabling improved cycle performance at 45 °C.Controlled droplet manipulation by light has tremendous technological potential. We report here a method based on photothermally induced pyroelectric effects that enables manipulation and maneuvering of a water droplet on a superhydrophobic surface fabricated on lithium tantalite (LiTaO3). In particular, we demonstrate that the pyroelectric charge distribution has an essential role in this process. Evenly distributed charges promote a rapid hydrophobic to hydrophilic transition featuring a very large water contact angle (WCA) change of ?76.5° in air. This process becomes fully reversible in silicone oil. In contrast, the localized charge distribution induced by guided laser illumination leads to very different and versatile functionalities, including droplet shape control and motion manipulation. The influence of a saline solution is also investigated and compared to the deionized water droplet. The focusing effect of the water droplet, a phenomenon that widely exists in nature, is particularly of interest. Simple tuning of the laser incident angle results in droplet deformation, jetting, splitting, and guided motion. Potential applications, such as droplet pinning and transfer, are presented. This approach offers a wide range of versatile functionalities and ready controllability, including contactless, electrodeless, and precise spatial and fast temporal control, with tremendous potential for applications requiring remote droplet control.Pseudomonas aeruginosa, is an opportunistic bacterium with a high prevalence in diverse pulmonary infections. Although several genes are involved in the system of resistance and evasion of the immunological response of the host, little is known about the inflammatory, degradative, and cell-binding response induced by P. aeruginosa in human lung alveolar epithelial cells. The purpose of this study was to determine the cytokine expression (IL-1β and TNFα), pro matrix metalloproteinases activation (proMMP-2 and proMMP-9), and the effects on the cell-binding adhesion protein (E-cadherin) in an in vitro model of human lung alveolar epithelial cells. A549 cells were stimulated with a different number of colony-forming units of P. aeruginosa for 3, 6, and 24 hours. Subsequently, the culture medium was collected, IL-1β and TNFα levels were evaluated by ELISA; proMMP-2 and -9 levels were determined by substrate gel zymography, and the MMP-9 and E-cadherin assessed by immunostaining of A549 cells. https://www.selleckchem.com/products/hs-10296.html Our results demonstrated that P. aeruginosa induces mainly the secretion of TNFα, increases actMMP-9 level, and significantly reduces the level of E-cadherin in the A549 cells. In summary, the inflammatory/degradative process induced by P. aeruginosa modulates the expression of the E-cadherin protein. The probable clinical implications of this study suggest the use of inhibitors that reduce the degradative activity of proMMP-9 which will be further explored in the next phase of this study.